“On-Water” Catalyst-Free Ecofriendly Synthesis of the Hantzsch Dihydropyridines

نویسندگان

  • Amit Pramanik
  • Manabendra Saha
  • Sanjay Bhar
چکیده

An eco-friendly "on-water" protocol for efficient catalyst-free synthesis of the Hantzsch dihydropyridines from aryl, heteroaryl, alkyl, and vinylogous aldehydes has been developed with minimum auxiliary substances, toxic reagents, organic solvents, and disposal problems.

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منابع مشابه

A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition

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Novel procedure for preparation of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition

An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields.

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A Novel protocol for synthesis of Hantzsch 1, 4- dihydropyridines using PEG-400 as a reaction medium and under catalyst-free condition

An efficient and expeditious catalyst-free procedure was developed for the one- pot synthesis of 1, 4-dihydropyridine derivatives via the three-component reaction of various aldehydes, ethyl acetoacetate, and ammonium acetate in PEG-400. The reaction was carried out at 110°С and the products were obtained in good to high yields.

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Nano Al2O3/KF using for synthesis of some Hantzsch type-products

A protocol for the synthesis of 1,4-dihydropyridines (Hantzsch type-products) was developed by means of a three-component condensation of an aldehyde, a β-dicarbonyl compound, ammonium acetate and nano Al2O3/KF as catalyst. This reaction was carried out under different conditions including i) solvent-free ii) and reflux in different solvents. In all conditions, the desired products were obtaine...

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Silica Boron Sulfonic Acid as Heterogeneous and Highly Efficient Solid Acid Catalyst For the Preparation of Hantzsch 1,4-dihydropyridines Under Solvent-Free

Silica boron sulfonic acid [SiO2–B(OSO3H)3] as an inexpensive, reusable, and Lewis and Brønsted acid catalyst was successfully synthesized, and used for the one-pot three-components synthesis of biologically active substituted Hantzsch 1,4-dihydropyridine derivatives  in the absence of solvent at 90ºC. Silica boron sulfonic acid is attractive and efficient, because it plays in two role as a Lew...

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عنوان ژورنال:

دوره 2012  شماره 

صفحات  -

تاریخ انتشار 2012